In this episode, my guest is Dr. Sean Mackey, M.D., Ph.D., Chief of the Division of Pain Medicine and Professor of Anesthesiology, Perioperative and Pain Medicine and Neurology at Stanford University School of Medicine. His clinical and research efforts focus on using advanced neurosciences, patient outcomes, biomarkers and informatics to treat pain.
We discuss what pain is at the level of the body and mind, pain thresholds, and the various causes of pain. We also discuss effective protocols for controlling and reducing pain, including the use of heat and cold, acupuncture, chiropractic, physical therapy, nutrition, and supplementation.
We also discuss how pain is influenced by our emotions, stress and memories, and practical tools to control one’s psychological perception of pain.
And we discuss pain medications, including the controversial use of opioids and the opioid crisis.
This episode will help people understand, manage, and control their pain as well as the pain of others.
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Dr. Sean Mackey
Stanford academic profile: https://stanford.io/48TgiBz
Website: https://drseanmackey.com
Publications: https://stanford.io/3U1OiHY
Lab website: https://stan.md/3vKrrWY
Stanford Division of Pain Medicine: https://stan.md/47zT9Dh
X: / drseanmackey
LinkedIn: / seancmackey
Journal Articles
Swearing as a response to pain: https://bit.ly/3O32Tir
Pain Mechanisms: A New Theory: https://bit.ly/3SiUGcq
Sex differences in pain: a brief review of clinical and experimental findings: https://bit.ly/3ShAebP
Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat: https://bit.ly/3ShFZGr
Viewing Pictures of a Romantic Partner Reduces Experimental Pain: https://bit.ly/3SiyNdi
Managing twin crises in chronic pain and prescription opioids: https://bit.ly/4aXuPht
The clinical use of mindfulness meditation for the self-regulation of chronic pain: https://bit.ly/3vC4ky0
Local immune response to food antigens drives meal-induced abdominal pain: https://go.nature.com/3TVMmAH
Effect of Electroacupuncture vs Sham Treatment on Change in Pain Severity Among Adults With Chronic Low Back Pain: https://bit.ly/4aQnxfz
Mindfulness-Based Stress Reduction, Cognitive Behavioral Therapy, and Acupuncture in Chronic Low Back Pain: https://bit.ly/3vuVBgS
Adverse Life Experiences and Brain Function: https://bit.ly/48WumKP
Oral Treatment With α-Lipoic Acid Improves Symptomatic Diabetic Polyneuropathy: The SYDNEY 2 trial: https://bit.ly/3TVMtw7
United States National Pain Strategy for Population Research: https://bit.ly/3U2Nrqi
Other Resources
TENS device: https://cle.clinic/48vzo0X
Acetyl-L-Carnitine in ALS Clinical Trial: https://bit.ly/47DqIUO
Empowered Relief: https://empoweredrelief.stanford.edu
National Pain Strategy: https://bit.ly/47z2Vp9
PainUSA: https://www.painusa.org
Timestamps
00:00:00 Dr. Sean Mackey
00:02:11 Sponsors: AeroPress, Levels & BetterHelp
00:06:13 Pain, Unique Experiences, Chronic Pain
00:13:05 Pain & the Brain
00:16:15 Treating Pain, Medications: NSAIDs & Analgesics
00:22:46 Inflammation, Pain & Recovery; Ibuprofen, Naprosyn & Aspirin
00:28:51 Sponsor: AG1
00:30:19 Caffeine, NSAIDs, Tylenol
00:32:34 Pain & Touch, Gate Control Theory
00:38:56 Pain Threshold, Gender
00:44:53 Pain in Children, Pain Modulation (Pain Inhibits Pain)
00:53:20 Tool: Heat, Cold & Pain; Changing Pain Threshold
00:59:53 Sponsor: InsideTracker
01:00:54 Tools: Psychology, Mindfulness-Based Stress Reduction, Catastrophizing
01:08:29 Tool: Hurt vs. Harmed?, Chronic Pain
01:12:38 Emotional Pain, Anger, Medication
01:20:43 Tool: Nutrition & Pain; Food Sensitization & Elimination Diets
01:28:45 Visceral Pain; Back, Chest & Abdominal Pain
01:34:02 Referenced Pain, Neuropathic Pain; Stress, Memory & Psychological Pain
01:40:23 Romantic Love & Pain, Addiction
01:48:57 Endogenous & Exogenous Opioids, Morphine
01:53:17 Opioid Crisis, Prescribing Physicians
02:02:21 Opioids & Fentanyl; Morphine, Oxycontin, Methadone
02:07:44 Kratom, Cannabis, CBD & Pain; Drug Schedules
02:18:12 Pain Management Therapies, Acupuncture
02:22:19 Finding Reliable Physicians, Acupuncturist
02:26:36 Chiropractic & Pain Treatment; Chronic Pain & Activity
02:31:35 Physical Therapy & Chronic Pain; Tool: Pacing
02:36:35 Supplements: Acetyl-L-Carnitine, Alpha Lipoic Acid, Vitamin C, Creatine
02:42:25 Pain Management, Cognitive Behavioral Therapy (CBT), Biofeedback
02:48:32 National Pain Strategy, National Pain Care Act
02:54:05 Zero-Cost Support, Spotify & Apple Reviews, YouTube Feedback, Sponsors, Momentous, Social Media, Neural Network Newsletter
#HubermanLab #Pain
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