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A 17-year-old opened fire at a small-town Iowa high school on the first day of school after the winter break, killing a sixth-grader and wounding five others as students barricaded in offices and fled in panic.

The suspect, a student at the school in Perry, died of what investigators believe is a self-inflicted gunshot wound, and at least one of the victims is a school administrator, a law enforcement official told The Associated Press. The official was not authorized to publicly discuss details of the investigation and spoke to The AP on condition of anonymity.

Perry has about 8,000 residents and is about 40 miles (64 kilometers) northwest of Des Moines, on the edge of the state capital's metropolitan area.

It is home to a large pork-processing plant, and low-slung, single story homes spread among trees now shorn of their leaves by winter. The high school and middle school are connected, sitting on the east edge of town.

Three gunshot victims were taken by ambulance to Iowa Methodist Medical Center in Des Moines, a spokesperson for its health system said. Some other patients were transported to a second hospital in Des Moines, a spokesperson for MercyOne Des Moines Medical Center confirmed, declining to comment on the number of patients or their statuses.

The shooting occurred in the backdrop of Iowa's first-in-the-nation presidential caucuses. GOP candidate Vivek Ramaswamy had a campaign event scheduled in Perry at 9 a.m. about 1 1/2 miles (2.4 kilometers) from the high school but canceled it to have a prayer and intimate discussion with area residents.

As of July 2021, Iowa does not require a permit to purchase a handgun or carry a firearm in public, though it mandates a background check for a person buying a handgun without a permit.